The aim of the study is to investigate the short- and long-term effects of a novel exergaming training program on cardiorespiratory fitness, severity of depression, and quality of life in patients with depressive disorders who are currently receiving standard treatment. Virtual reality-based exergaming is described as particularly motivating, which is why it may be well suited to reaching patients with low motivation to exercise. In addition, the study aims to better understand the biological, cognitive, and psychological mechanisms responsible for the antidepressant effects of physical activity. It will also test whether wearing a wearable device (Oura Ring) has an additional effect on patients' exercise behavior after they leave the clinic. In addition, the study aims to use qualitative research methods to find out how the new training program is perceived by patients and medical staff.

The study makes an important contribution to clinical practice by investigating whether a novel sports and exercise therapy program can be integrated into the standard care of patients with major depression. The intervention has the potential to positively influence the course of therapy (e.g., severity of depression, quality of life). Improving cardiorespiratory fitness through exergaming can also lead to a reduced risk of cardiovascular disease in the long term. Due to its widespread prevalence, major depression places a considerable burden on the healthcare system from a societal perspective. Findings on the extent to which the effects of sports and exercise therapy can be optimized through novel interventions are therefore of great importance from a public health promotion perspective.

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